GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs7267979 | 1 | rs11087521 | chr20:25440648 | FAM182A | chr20:26035250-26067552:+ | -0.25 | -6.47 | 1.52E-10 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs7267979 | 1 | rs11087521 | chr20:25440648 | FAM182B | chr20:25744102-25848786:- | 0.23 | 5.75 | 1.17E-8 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs11088226 | 1 | rs11088226 | chr21:33925531 | TCP10L | chr21:33947152-33957845:- | -0.28 | -5.85 | 6.61E-9 | Gastritis |
| BRCA | cis | rs9876781 | 1 | rs1109227 | chr3:48479207 | TREX1 | chr3:48501186-48509043:+ | -0.29 | -10.82 | 5.75E-26 | Longevity |
| BRCA | cis | rs1109501 | 1 | rs1109501 | chr4:71329490 | AMTN | chr4:71384298-71398459:+ | 0.26 | 7.61 | 5.79E-14 | Alcoholism (heaviness of drinking) |
| BRCA | cis | rs1061377 | 1 | rs11096982 | chr4:39134867 | KLHL5 | chr4:39046659-39123828:+ | -0.14 | -4.51 | 7.36E-6 | Uric acid levels |
| BRCA | cis | rs11097912 | 1 | rs11097912 | chr4:107000462 | TBCK | chr4:106967233-107237861:- | 0.23 | 7.27 | 7.08E-13 | Airflow obstruction |
| BRCA | cis | rs7267979 | 1 | rs11100 | chr20:25281184 | FAM182A | chr20:26035250-26067552:+ | -0.2 | -5.4 | 8.27E-8 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs7267979 | 1 | rs11100 | chr20:25281184 | FAM182B | chr20:25744102-25848786:- | 0.23 | 5.94 | 3.95E-9 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs17030613 | 1 | rs1110042 | chr1:113236534 | ST7L | chr1:113066142-113162405:- | 0.58 | 12.99 | 6.52E-36 | Diastolic blood pressure;Blood pressure |
| BRCA | cis | rs7894051 | 1 | rs11101721 | chr10:135190358 | PAOX | chr10:135192741-135205197:+ | -0.2 | -3.6 | 0.00033 | Lifespan |
| BRCA | cis | rs1110183 | 1 | rs1110183 | chr9:38456365 | EXOSC3 | chr9:37779949-37785067:- | 0.18 | 4.12 | 4.13E-5 | Hypertension |
| BRCA | cis | rs1110183 | 1 | rs1110183 | chr9:38456365 | TOMM5 | chr9:37582646-37592636:- | 0.12 | 4.14 | 3.82E-5 | Hypertension |
| BRCA | cis | rs10860757 | 1 | rs11110901 | chr12:102030113 | CHPT1 | chr12:102091417-102123424:+ | -0.23 | -3.6 | 0.000333 | Lung function (FEV1) |
| BRCA | cis | rs10444533 | 1 | rs11113118 | chr12:107199142 | C12orf23 | chr12:107349544-107367811:+ | -0.17 | -4.38 | 1.33E-5 | Social autistic-like traits |